Anastas V, Chavdoula E, La Ferlita A, Soysal B, Cosentini I, Nigita G, Kearse MG, Tsichlis PN. KDM2B is required for ribosome biogenesis and its depletion unequally affects mRNA translation. submitted bioRxiv pre-print: https://doi.org/10.1101/2024.05.22.595403
Cheng Z, I Saiful, Kanlong JG, Sheppard M, Seo H, Nikolaitchik OA, Kearse MG, Pathak VK, Musier-Forsyth K, Hu WS. (2024) Translation of HIV-1 unspliced RNA is regulated by 5′ untranslated region structure. Journal of Virology, 98(10): e0116024. PMID: 39315813
Scarpitti MR, Pastore B, Tang W, Kearse MG. (2024) Characterization of ribosome stalling and no-go mRNA decay stimulated by the Fragile X protein, FMRP. Journal of Biological Chemistry, 300(8): 107540. PMID: 38971316 (bioRxiv pre-print version: https://doi.org/10.1101/2024.02.02.577121)
Grove DJ*, Russell PJ*, Kearse MG. (2024) To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1•DENR to deliver initiator tRNA to ribosomes. WIREs RNA, 15(2): e1833. PMID: 38433101
*equal contribution
Grove DJ, Levine DJ, Kearse MG. (2023) Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits. Nucleic Acids Research, 51(18): 9983-10000. PMID: 37602404 (bioRxiv pre-print version: https://doi.org/10.1101/2022.11.18.517125)
Scarpitti MR and Kearse MG. (2023) In vitro analysis of stalled ribosomes using puromycin incorporation. Bio-protocol, 13(16): e4744. PMID: 37638299
Russell PJ, Slivka JA, Boyle EP, Burghes AHM, Kearse MG. (2023) Translation re-initiation after uORFs does not fully protect mRNAs from nonsense-mediated decay. RNA, 29(6): 735-744. PMID: 36878710 (bioRxiv pre-print version: https://doi.org/10.1101/2022.01.10.475702)
Scarpitti MR, Warrick JE, Yoder EL, Kearse MG. (2022) A noncanonical RNA-binding domain of the fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadruplexes. Journal of Biological Chemistry, 298(12): 102660. PMID: 36328245 (bioRxiv pre-print version: https://doi.org/10.1101/2022.01.10.475703)
•Selected as a JBC Editors’ Pick
•Highlighted in Journal of Biological Chemistry, 299(1): 102773
•Highlighted by the OSU Medical Center Research News
DiVita DJ and Kearse MG. (2021) A double on the Rocs with a twist: Rocaglamide A targets multiple DEAD-box helicases to inhibit translation initiation. Cell Chemical Biology, (28)4: 431-433. PMID: 33861954
Rodriguez CM*, Wright SE*, Kearse MG, Haenfler JM, Flores BN, Liu Y, Ifrim MF, Glineburg MR, Krans A, Jafar-Nejad P, Sutton MA, Bassell GJ, Parent JM, Rigo F, Barmada SJ, Todd PK. (2020) A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis. Nature Neuroscience, 23(3): 386-397. PMID: 32066985
*equal contribution
Green KM, Sheth U, Flores BN, Wright SE, Sutter A, Kearse MG, Barmada S, Ivanova MI, Todd PK. (2019) High-throughput screening yields several small molecule inhibitors of repeat-associated non-AUG translation. Journal of Biological Chemistry, 294(49): 18624-18638. PMID: 31649034
•Highlighted in Trends in Pharmaceutical Sciences, 41(2): 71-73
Kearse MG, Goldman DH, Choi J, Nwaezeapu C, Liang D, Green KM, Goldstrohm AC, Todd PK, Green R, Wilusz JE. (2019) Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors. Genes & Development, 33(13-14): 871-885. PMID: 31171704
•Recommended by F1000
Li Z, Kearse MG, Huang C. (2018) The nuclear export of circular RNAs is primarily defined by their length. RNA Biology, 6(1): 1-4. PMID: 30526278
Mageeney CM*, Kearse MG*, Gershman BW, Pritchard CE, Colquhoun JM, Ware VC. (2018) Functional interplay between ribosomal protein paralogues in the eRpL22 family in Drosophila melanogaster. Fly, 12(3-4):143-163. PMID: 30465696
*equal contribution
Green KM, Glineburg MB*, Kearse MG*, Flores B, Linsalata AE, Fedak SJ, Goldstrohm AC, Barmada S, Todd PK. (2017) RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response. Nature Communications, 8(1): 2005. PMID: 29222490
*equal contribution
Kearse MG, Wilusz JE. (2017) Non-AUG translation: a new start for protein synthesis in eukaryotes. Genes & Development, 31(17): 1717-1731. PMID: 28982758
Kearse MG, Green KM, Krans A, Rodriquez CM, Linsalata AE, Goldstrohm AC, Todd PK. (2016) CGG Repeat-associated non-AUG translation utilizes a cap-dependent, scanning mechanism of initiation to produce toxic proteins. Molecular Cell, 62(2): 314-322. PMID: 27041225
•Previewed in Molecular Cell, 62(2): 155-156
•Highlighted in Nature Reviews Molecular Cell Biology, 17: 264
Krans A, Kearse MG, Todd PK. (2016) Repeat associated non-AUG translation from antisense CCG repeats in Fragile X Tremor/Ataxia. Annals of Neurology, 80(6): 871-881. PMID: 27761921
Kearse MG, Todd PK. (2014) RAN translation and its impact in neurodegenerative disease. Neurotherapeutics, 11(4): 721-731. PMID: 25005000
Fischl MJ, Weimann SR, Kearse MG, Burger RM. (2014) Slowly emerging glycinergic transmission enhances inhibition in the sound localization pathway of the avian auditory system. Journal of Neurophysiology, 111(3): 565-572. PMID: 24198323 (link)
Kearse MG, Ireland JA, Prem SM, Chen AS, Ware VC. (2013) RpL22e, but not RpL22e-like-PA, is SUMOylated and localizes to the nucleoplasm of Drosophila meiotic spermatocytes. Nucleus, 4(3): 241-258. PMID: 23778934
•Selected for Cover Image
Gatto GJ Jr, Ao Z, Kearse MG, Zhou M, Morales CR, Daniels E, Bradley BT, Goserud MT, Goodman KB, Douglas SA, Harpel MR, Johns DG. (2013) NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation. Journal of Enzyme Inhibition and Medicinal Chemistry, 28(1): 95-104. PMID: 22136506
Kearse MG, Chen AS, Ware VC. (2011) Expression of ribosomal protein L22e family members in Drosophila melanogaster: rpL22-like is differentially expressed and alternatively spliced. Nucleic Acids Research, 39(7): 2701-2716. PMID: 21138957